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Clinical Skin PolyPeptide Firming Serum

CLINICAL SKIN PolyPeptide Firming Serum - 1.7 oz / 50 ml An award-winning, age-defying serum designed to address signs of aging.  Formulated with multi-tasking peptides, antioxidants, ceramides, and hyaluronic acid. Clinically proven* to: Increase skin firmness and elasticity by 29.7% Reduce the appearance of fine line

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CLINICAL SKIN PolyPeptide Firming Serum - 1.7 oz / 50 ml

  • An award-winning, age-defying serum designed to address signs of aging. 
  • Formulated with multi-tasking peptides, antioxidants, ceramides, and hyaluronic acid.
  • Clinically proven* to:
    • Increase skin firmness and elasticity by 29.7%
    • Reduce the appearance of fine lines and wrinkles by 22.5%
    • Improve moisturization by 77.4%

Improvement in the appearance of the signs of aging observed as early as 4 weeks*.

*Results based on a single-blinded 12-week clinical study of 35 subjects that applied PolyPeptide Firming Serum twice-daily. Data on file with Clinical Skin.

(See Clinical Skin for Instructions & ingredients)


Minimizing wrinkles and a lifted appearance.

Clinically Proven to

FORTIFY: Increase skin firmness and elasticity to combat signs of aging

SUPPORT: Reduce the appearance of fine lines and wrinkles

MOISTURIZE: Improve skin moisture for a healthier appearance


- Fine lines

- Loss of Elasticity

- Loss of Firmness

- Wrinkles

- Decreased Hydration


- Delicate

- Non-Oily

- Quick Absorbing

Visible Results

- 97% reported more elasticity and a softer feel

- 74%* reported evened out skin tone

- 74%* reported less visible fine lines and wrinkles

View clinical & user trials »
IDEAL FOR: those who want younger, healthier looking skin while reducing the look of wrinkles and lines.


Key Peptides

Copper Peptide
Bis (Tripeptide-1) Copper Acetate can help to support collagen and elastin, which can result in the reduction of fine lines, enlarged pores and signs of aging.
Acetyl Hexapeptide-8 works to help soften wrinkles while promoting a collagen-rich appearance to result in firmer looking skin.
Palmitoyl Tripeptide-38 is a protein fragment which works to help skin maintain its structure while minimizing uneven skin tone and dullness.
Palmitoyl Tripeptide-28
Palmitoyl Tripeptide-28 contributes to improvements in skin elasticity, firmness, and has soothing capabilities.

Supporting Ingredients

Hyaluronic Acid

All Ingredients

Water, Glycerin, Propanediol, Polyacrylate Crosspolymer-6, Tocopheryl Acetate, Acetyl Hexapeptide-8, Bis (Tripeptide-1) Copper Acetate, Palmitoyl Tripeptide-28, Palmitoyl Tripeptide-38, Ceramide AP, Ceramide EOP, Ceramide NP, Ceramide NG, Cholesterol, Phytosphingosine, Sodium Hyaluronate, Ascorbic Acid, Ergothioneine, Glutathione, Plankton Extract, Hydroxypropyl Cyclodextrin, Micrococcus Lysate, Xanthan Gum, Coco-Caprylate, Tetrasodium Glutamate Diacetate, Potassium Sorbate, Carbomer, Sodium Benzoate, Acetic Acid, Lecithin, Sodium Lauroyl Lactylate, Ethylhexylglycerin, Phenoxyethanol, Evodia Rutaecarpa Fruit Extract, Arabidopsis Thaliana Extract, Copper PCA, Zinc PCA, Kaolin

How to Apply

The PolyPeptide Firming Serum

Apply 7-10 drops of serum on freshly cleansed and dried skin
Gently massage into face, neck and décolleté, avoiding direct contact with the eyes
Repeat AM + PM
For external use only. If contact with eyes occurs, rinse thoroughly with water. Discontinue use if signs of irritation or rash appear. Keep out of reach of children.

Results Through Research.

Polypeptide Firming Serum is clinically proven* to show statistically significant improvements in the appearance of skin elasticity, fine lines, wrinkles and more.


improvement in skin firmness and elasticity


reduction in appearance of fine lines in just 3 months


improvement in moisturization

Swipe for more
*Results based on a U.S. based single-blinded 12-week clinical study of 35 subjects that applied Polypeptide Firming Serum twice daily. Data on file.

Clinical Study Participants Reported

Substantial Results

97%* More elasticity and a softer feel

94%* Overall improvement in skin’s appearance

84%* Healthier looking skin

94%* Overall improvement in skin’s appearance

74%* Less visible fine lines and wrinkles

*Percentage of subjects who reported improvement

Dermatologist Acclaimed

“Clinical Skin Polypeptide firming serum is the perfect blend of excellent ingredients with the right technology. It's able to deliver safe and effective results that have been shown in clinical studies, performing excellent as a maintenance program for my injectable and laser patients that want to maintain a medical skin grade skin care routine at home.

I endorse the product because it has been shown to reduce fine lines and improve skin texture as well as deliver firm skin in a very clean serum which is made for all skin types including sensitive skin.”

Dr. Bertha Baum, Board-Certified Dermatologist

Dermatologist Acclaimed

"This multi-tasking treatment serum has become my “go to” for patients seeking the ultimate in skin firming and reduction in the appearance of fine lines and crepiness on the face, neck and decollate. Enhanced with copper peptide, Argireline and ceramides, its creamy, yet light serum consistency promotes a smooth and supple skin texture and serves as a key component of my patients’ home skincare regimen as well as a routine paring for my anti-aging in office procedures."

Dr. Lisa R Ginn, M.D., F.A.A.D. Board Certified Dermatologist Fellowship-trained Cosmetic Laser Surgeon

Customer Reviews

Based on 186 reviews
Donna D.

I’ve been using Obagi C skin care for around 20 years. I recently switched to Obagi clinical. It’s so amazing! After two weeks my sun spots are disappearing, my skiing looks so vibrant and smooth. I highly recommend the Polypeptide lotion along with the retinal cream and the Clinical pro-collagen serum! I love them. My skin looks so much younger, vibrant, soft and dewy. Beautiful! Skincare Essentials packed the kit so elegantly. It was like opening a special gift. Thank you!

Katherina J.
Firmer skin

My skin is firmer, looks fresher. Wrinkles are very faint now. Thank you

Diedra R.

So far so good. I have noticed less fine lines and my face looks smooth. Just working on my eyes to look more youthful

renny sobari
Very good

This make my skin soft

Meredith B.
It’s absolutely amazing

I will be 50 this year, and I have some nasty lines around my eyes from how I mostly sleep. Granted there’s age lines, sun damage, and texture issues too. I used the stuff for less than a week, twice a day and cannot believe the difference in my wrinkles and my texture. I immediately bought a second bottle, so I’d have it on hand. I use it in the morning after my vitamin C, and before my moisturizer, and I use it at night after my retinol before moisturizer. I am a product junkie and this Has to be the most wow product I have used in a while.